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Tikun Olam cannabis oil is a botanical drug product developed by the Israeli company Tikun Olam. It is a standardized cannabinoid-containing oil formulation designed to modulate appetite and nutritional status, primarily through the activation of endocannabinoid receptors CB1 and CB2. The product has been investigated in Phase 3 clinical trials for the treatment of protein-energy malnutrition and appetite disorders in patients undergoing hemodialysis. While the company produces various specific strains (such as Avidekel and Alaska), the lead 'Cannabis Oil' program specifically targeted nutritional support in chronic disease states. The Phase 3 trial for malnutrition was subsequently withdrawn.
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