Drug intelligence / Profile preview

tilia viridis extract

Development stage
Unknown
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Tilia viridis extract is a **botanical extract from the flowers or leaves of the Tilia × viridis tree**, a hybrid lime tree species. Tilia genus species have been widely used in traditional medicine for their sedative, anxiolytic, anticonvulsant, anti-inflammatory, antioxidant, and antiproliferative activities. The extract is rich in flavonoids such as quercetin, rutin, isoquercitrin, and kaempferol, which contribute to its main bioactivities. Notably, the extract demonstrates **antioxidant effects, acting as a scavenger of reactive oxygen species (ROS)** including hydrogen peroxide and superoxide anion, and has a **selective antiproliferative effect on some tumor cell lines**, potentially via modulation of oxidative stress. Its mechanism for central nervous system effects is thought to involve both antioxidant activity and modulation of GABAergic and serotoninergic neurotransmission. Traditional indications include anxiety, sleep disorders, colds, fever, cough, and as a neuroprotective and anti-inflammatory agent[1][2][3].

Other names
linden extractTilia × viridis extractlime flower extractbasswood extract
02

Targets

GABRR (GABA-A receptor subunit rho)HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))

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