Drug intelligence / Profile preview

tiliacora triandra leaf extract

Development stage
Preclinical
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

**Tiliacora triandra leaf extract** is a botanical extract derived from the leaves of *Tiliacora triandra*, a medicinal plant used traditionally in Thailand. Based on the provided preclinical publication, it is being investigated as a neuroprotective and cognition-enhancing agent for memory impairment related to Alzheimer's disease. In a scopolamine-induced cognitive impairment rat model, the extract improved performance in behavioral memory tests and was associated with reduced acetylcholinesterase activity, reduced malondialdehyde levels, increased antioxidant enzyme activity, and increased hippocampal neuronal density, suggesting a multifactorial mechanism involving cholinergic modulation and attenuation of oxidative stress rather than a single defined molecular target. No specific commercial developer, manufacturer, brand name, or clinical-stage development program is established from the provided evidence.

Other names
Tiliacora triandra leaf extractT. triandra leaf extract
02

Targets

G6PC1 (Glucose 6-phosphatase alpha)AcetylcholinesteraseHDAC (HDAC family)PEPCK (Phosphoenolpyruvate carboxykinase 1)

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