Tim-3 small molecule inhibitor

A Tim-3 small molecule inhibitor is a class of small molecule compounds designed to target and inhibit T-cell immunoglobulin and mucin domain-containing protein 3 (Tim-3), an immune checkpoint receptor. Tim-3 is expressed on various immune cells, including T cells, natural killer (NK) cells, and macrophages. In the context of pulmonary fibrosis, Tim-3 inhibition has been shown to regulate macrophage polarization, specifically suppressing the activation of Stat3 signaling pathways, which in turn inhibits the activation and proliferation of fibroblasts. In oncology, small molecule inhibitors of Tim-3 block its interaction with ligands such as galectin-9, phosphatidylserine (PtdSer), HMGB1, and CEACAM1, thereby restoring T-cell and NK-cell function and enhancing anti-tumor immunity.

Other names

TIM-3 small molecule inhibitorTIM3 small molecule inhibitorTIM 3 small molecule inhibitorTIM-3 small-molecule inhibitorTIM3 small-molecule inhibitorTIM 3 small-molecule inhibitor