timolol + carboxymethylcellulose

Timolol + carboxymethylcellulose is a fixed-dose combination ophthalmic formulation containing timolol, a non-selective beta-adrenergic receptor antagonist (beta-blocker), and carboxymethylcellulose, an ocular lubricant and bioadhesive polymer. Timolol reduces intraocular pressure by decreasing aqueous humor production in the eye, making it effective for treating open-angle glaucoma and ocular hypertension. Carboxymethylcellulose acts as a lubricant to relieve dry or irritated eyes and enhances the retention time of timolol on the ocular surface, potentially improving tolerability and efficacy while reducing local toxicity associated with preservatives. This combination is designed to provide both intraocular pressure reduction and symptomatic relief of dry eye symptoms[1][2][6].