Drug intelligence / Profile preview

tinospora cordifolia

Development stage
Unknown
Lead developer
SourceOne Global Partners
Modality
Small Molecules
Administration
Oral, Topical
01

Overview

Tinospora cordifolia, also known as guduchi or amrita, is a climbing shrub widely used in traditional Ayurvedic medicine, primarily in India. It contains various bioactive compounds—glycosides, diterpenoid lactones, alkaloids, phenolics, essential oils, polysaccharides, and tinosporaside—which are believed to contribute to its antioxidant, immunomodulatory, anti-inflammatory, hepatoprotective, antidiabetic, and hypolipidemic effects. Its principal mechanisms include modulation of immune function and inhibition of oxidative stress through free radical scavenging. Modern clinical evidence for its efficacy remains limited, with the most robust data supporting effects on glycemic control in type 2 diabetes. It is available in standardized extracts and marketed as dietary supplements, but there is no substantial regulatory approval for pharmaceutical indications outside of traditional medicine systems[1][2][3][4][5].

Brand names
Tinofend
Other names
amritaduyutigegadogalogiloegiloyaguduchigulanchaheartleaf moonseedteppatigetinosporatinospora stem extract
02

Targets

JNK (Mitogen-activated protein kinase kinase kinase family)CETPPPARG (Peroxisome proliferator-activated receptor gamma)AdipoR (Adiponectin receptor)AMY (Pancreatic alpha-amylase)

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