Drug intelligence / Profile preview

tinospora cordifolia extract

Development stage
Preclinical
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Tinospora cordifolia extract is a botanical extract derived from the medicinal plant *Tinospora cordifolia*, widely known as Guduchi or Giloy in Ayurvedic medicine. The extract contains a complex mixture of bioactive constituents, including alkaloids, glycosides, flavonoids, terpenoids, and polysaccharides. It is primarily recognized for its immunomodulatory, anti-inflammatory, and antioxidant properties. Research indicates that the extract may exert neuroprotective effects by suppressing the NF-κB signaling pathway, thereby modulating the production of pro-inflammatory cytokines such as IL-1β and enhancing anti-inflammatory cytokines like IL-10. It has been investigated in preclinical and clinical research settings for potential applications in Parkinson's disease, diabetes mellitus, HIV-1 reverse transcriptase inhibition, and multidrug-resistant bacterial infections.

Other names
GuduchiGiloyTinospora cordifoliaTinosporia cordiofolia
02

Targets

IL10 (Interleukin-10)IL1B (Interleukin-1 beta)Neuraminidase

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