Drug intelligence / Profile preview

tinzaparin + dalteparin

Development stage
Unknown
Lead developer
LEO Pharma
Modality
Small Molecules
Administration
Subcutaneous, Intravenous
01

Overview

Tinzaparin and dalteparin are both low molecular weight heparins (LMWHs) used as anticoagulants. They are produced by different depolymerization processes of unfractionated heparin. Tinzaparin is produced by enzymatic depolymerization (heparinase digestion) while dalteparin is produced by controlled nitrous acid depolymerization. Both drugs work by potentiating the activity of antithrombin III, which inhibits the formation of factor Xa and thrombin, with a preference for inactivating factor Xa. They are used for the prevention and treatment of deep vein thrombosis, pulmonary embolism, and other thromboembolic conditions.

Brand names
Innohep + Fragmin
02

Targets

ATIII (Antithrombin III)F10 (Factor Xa)

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