Drug intelligence / Profile preview

TIRV HA

Development stage
Unknown
Lead developer
Pfizer
Modality
Vaccines & Immunotherapeutics, mRNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
01

Overview

**TIRV HA** is a reported investigational trivalent modified messenger RNA influenza vaccine candidate. It is described as a lipid nanoparticle-formulated nucleoside-modified mRNA vaccine encoding full-length influenza hemagglutinin antigens, intended to induce protective humoral and cellular immunity against seasonal influenza A and influenza B viruses. Public sources verify related Pfizer and BioNTech trivalent influenza mRNA vaccine programs and an hVIVO-sponsored influenza A/H1N1 modRNA human-challenge study, but they do not clearly verify the exact designation \"TIRV HA\" or establish it as a distinct named clinical asset.

Other names
Trivalent Influenza RNA Vaccine Hemagglutinin Antigen
02

Targets

Influenza hemagglutinin-specific B-cell receptorInfluenza hemagglutinin-specific T-cell receptorHost ribosomal translation machineryHA0 (Influenza B virus hemagglutinin)

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