tissue engineered partial laryngeal implant

The tissue engineered partial laryngeal implant (TEPLI) is an Advanced Therapy Medicinal Product (ATMP) and medical device combination designed for laryngeal reconstruction following partial laryngectomy. Developed by Videregen, the implant consists of a decellularized porcine or cadaveric laryngeal scaffold that retains the natural three-dimensional extracellular matrix (ECM) architecture while being rendered non-immunogenic. This scaffold is typically seeded with autologous mesenchymal stem cells (MSCs) derived from the patient's bone marrow. Once implanted, the scaffold provides structural support for the airway while the MSCs facilitate site-specific tissue regeneration and epithelialization through paracrine signaling and differentiation. The primary clinical indication is for patients with T2-T3 laryngeal cancer undergoing partial laryngectomy, with the goal of preserving functional vocalization, swallowing, and airway patency without the need for a permanent tracheostomy.

Other names

tissue-engineered partial laryngeal implantVideregen laryngeal implantdecellularized laryngeal scaffold