titrated oral misoprostol solution

Titrated oral misoprostol solution is a liquid formulation of the synthetic prostaglandin E1 (PGE1) analog, misoprostol, being evaluated by China Medical University Hospital for labor augmentation. Misoprostol acts as an agonist at prostaglandin E receptors (primarily the EP3 subtype) in the uterine myometrium, which triggers intracellular calcium release and leads to potent uterine contractions. While traditionally administered as a tablet for gastric ulcer prevention or off-label for labor induction, this specific titrated oral solution allows for precise dose adjustments to achieve adequate uterine activity while minimizing the risk of uterine tachysystole. A Phase 4 randomized controlled trial (NCT02433106) compares this titrated oral regimen to the standard of care, intravenous oxytocin, in pregnant women experiencing inadequate uterine contractions during labor.

Brand names

Cytotec

Other names

oral misoprostol solutionmisoprostol solution