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tivozanib
- Development stage
- Approved
- Lead developer
- AVEO Oncology
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Allosteric Modulators → Classical Binding Small Molecules → Small Molecules, Irreversible Covalent Inhibitors → Covalent Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Tivozanib is an oral, small molecule tyrosine kinase inhibitor used to treat advanced renal cell carcinoma (RCC) in adults who have failed at least two prior systemic therapies or whose disease has relapsed. It works by selectively inhibiting the phosphorylation of vascular endothelial growth factor receptors (VEGFR)-1, -2, and -3, thereby suppressing angiogenesis and tumor growth. Tivozanib also inhibits other kinases such as c-kit and platelet-derived growth factor receptor beta (PDGFR-β). The drug was developed by Kyowa Kirin and is marketed under the brand name Fotivda by Aveo Oncology. Tivozanib was approved by the FDA in March 2021 for use in relapsed or refractory advanced RCC[3][5][6][8].
- Brand names
- Fotivda
- Other names
- tivozanib hydrochloride monohydrate
02
Targets
VEGFR2 (Vascular endothelial growth factor receptor 2)KIT (c-KIT proto-oncogene receptor tyrosine kinase)TEK (Tie2)PDGFRA (Platelet-derived growth factor receptor alpha)EPHB2 (Ephrin type-B receptor 2)PDGFRB (Platelet-derived growth factor receptor beta)VEGFR-1 (Vascular endothelial growth factor receptor 1)VEGFR3 (Vascular endothelial growth factor receptor 3)
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