tixocortol pivalate

**Tixocortol pivalate** is a synthetic corticosteroid and 21-thiol derivative of hydrocortisone classified as a class A steroid, featuring topical anti-inflammatory properties with minimal systemic glucocorticoid or mineralocorticoid activity due to rapid liver metabolism and transformation in red blood cells. It acts as a glucocorticoid receptor agonist and histone deacetylase 2 stimulator, reducing inflammation locally in conditions like rhinitis, pharyngitis, and ulcerative colitis. Primarily administered via nasal sprays, lozenges, enemas, or rectal solutions, it is also used in patch testing to screen for contact allergies to class A corticosteroids and is marketed under names like Pivalone.[1][2][3][4][5][6][7]

Brand names

PivaloneProcolonRectovaloneTivalon-NTTiprederm

Other names

11beta,17-Dihydroxy-21-mercaptopregn-4-ene-3,20-dione 21-pivalate(11beta)-21-[(2,2-dimethyl-1-oxo-propyl)thio]-11,17-dihydroxypregn-4-ene-3,20-dioneT-031T031T 031T-031AT031AT 031A