tizanidine

Tizanidine is a centrally acting skeletal muscle relaxant primarily used to manage spasticity associated with conditions such as multiple sclerosis and spinal cord injury. It acts as an agonist at alpha2 adrenergic receptors (mainly the alpha2A subtype) in the central nervous system, inhibiting presynaptic motor neuron activity and reducing the release of excitatory neurotransmitters like glutamate and aspartate. This results in decreased muscle tone and relief from spasms[1][3][5][7]. Tizanidine is available in oral formulations (tablet, capsule, solution) and has a relatively short half-life (~2.5 hours). Common side effects include dry mouth, drowsiness, weakness, dizziness; serious risks include hypotension and liver dysfunction[1][6]. Developed by Novartis (originally), it is now widely available as a generic medication.

Brand names

ZanaflexSirdaludOntralfy

Other names

盐酸替扎尼定tizanidine hydrochloride4-Chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-8-thia-7,9-diazabicyclo[4.3.0]nona-2,4,6,9-tetraen-5-amine