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TJ12-NP
- Development stage
- Preclinical
- Lead developer
- Tsinghua University
- Modality
- Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
TJ12-NP is a glypican-3 (GPC3)-targeted nanoparticle developed for image-guided liver cancer surgery. GPC3 is a tumor-associated antigen highly expressed in hepatocellular carcinoma (HCC) and certain metastatic liver cancers, but absent in normal hepatocytes. TJ12-NP can be labeled with imaging agents such as Cy5 or indocyanine green (ICG) to enable high-contrast tumor visualization and fluorescence-guided tumor resection. In preclinical studies using patient-derived liver organoids and in vivo mouse models, TJ12-NP demonstrated strong, tumor-selective accumulation and facilitated complete fluorescence-guided resection of GPC3-positive tumors.
- Other names
- TJ12 nanoparticleTJ-12 nanoparticleTJ 12 nanoparticleTJ12-NP GPC3-targeted nanoparticleTJ-12-NP GPC3-targeted nanoparticleTJ 12-NP GPC3-targeted nanoparticle
02
Targets
GPC3 (Glypican-3)
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