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TJO-087
- Development stage
- Phase 3
- Lead developer
- Taejoon Pharmaceutical
- Modality
- Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Small Molecules
- Administration
- Ophthalmic
01
Overview
TJO-087 is a 0.08% nanoemulsion formulation of cyclosporine A (CsA) developed for the treatment of dry eye disease. It is designed to improve ocular tolerability and achieve therapeutic efficacy with a lower concentration compared to conventional CsA formulations[1][4]. Cyclosporine A acts as an immunosuppressant by inhibiting calcineurin, thereby suppressing T cell activation and reducing inflammation on the ocular surface[8]. Clinical studies have shown that once-daily administration of TJO-087 provides significant improvement in symptoms and signs of dry eye disease, with tolerability comparable to standard CsA treatments[1][4]. The drug is being developed by Taejoon Pharm.
- Brand names
- Cyporin NCyporin N Eye drop 0.05%TJCS eye drop
- Other names
- cyclosporine ophthalmic nanoemulsion0.08% nanoemulsion cyclosporine A
02
Targets
CN (Calcineurin)ABCB1 (P-glycoprotein)
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