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Drug intelligence / Profile preview
TK-254RX
- Development stage
- Unknown
- Lead developer
- Teikoku Pharma USA
- Modality
- Small Molecules
- Administration
- Topical
01
Overview
TK-254RX is an investigational topical hydrogel patch containing 1.5% esflurbiprofen (the S-enantiomer of flurbiprofen), developed by Teikoku Seiyaku Co., Ltd. for the treatment of acute pain and soft tissue injuries such as contusions, sprains, and strains. The patch utilizes proprietary Hydrohesive® technology, a hydrophilic adhesive formulation designed for once-daily application. As a nonsteroidal anti-inflammatory drug (NSAID), esflurbiprofen acts by inhibiting cyclooxygenase (COX) enzymes, thereby reducing the production of prostaglandins that mediate pain and inflammation. This topical delivery system is intended to provide localized relief with lower systemic exposure compared to oral NSAIDs, potentially reducing the risk of gastrointestinal and cardiovascular side effects.
- Other names
- esflurbiprofen patchS-flurbiprofen patchesflurbiprofen 1.5% hydrogel patch
02
Targets
PGHS-1 (Prostaglandin G/H Synthase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)
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