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TKCell + FOLFOX-4
- Development stage
- Unknown
- Lead developer
- Binex
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Cell Therapies, DNA Intercalators/Alkylators → Nucleic Acid-Directed Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
- Administration
- Intravenous
01
Overview
TKCell + FOLFOX-4 is a **combination therapy** comprising TKCell, a cell therapy-based investigational drug likely involving chimeric antigen receptor T cells (CAR-T) or related engineered T cells with antitumor properties, combined with the FOLFOX-4 chemotherapy regimen. FOLFOX-4 consists of folinic acid (leucovorin), fluorouracil (5-FU), and oxaliplatin, and is used primarily for the treatment of colorectal and other gastrointestinal cancers. FOLFOX-4 components exert antineoplastic effects by impairing DNA synthesis and function in cancer cells. TKCell, as a cell therapy, is likely engineered to enhance immune-mediated tumor cell killing. This combination is used in settings designed to maximize tumor cytotoxicity through both cytotoxic chemotherapy and cell therapy, potentially for investigational indications in solid or hematologic malignancies.
- Brand names
- TKCell + FOLFOX-4
- Other names
- TKCell plus FOLFOX-4
02
Targets
DNADHFR (Dihydrofolate reductase)TS (Thymidylate synthase)
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