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TLX593-Px
- Development stage
- Unknown
- Lead developer
- Telix Pharmaceuticals
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous
01
Overview
TLX593-Px is a novel radiopharmaceutical PET imaging agent designed to target Prostate-Specific Membrane Antigen (PSMA). It is developed using the AlFluor platform, which utilizes an aluminum-fluoride (AlF) chemistry to enable the rapid, one-step radiolabeling of molecules with Fluorine-18 (18F). This approach combines the high-resolution imaging characteristics of 18F with the specificity of PSMA-targeting ligands. The agent was acquired by Telix Pharmaceuticals through a strategic agreement with University Hospital Ghent and Ghent University, which provided Telix with a comprehensive CMC package and clinical data from a Phase 3 trial. TLX593-Px is primarily intended for the detection, staging, and monitoring of prostate cancer.
02
Targets
CA9 (Carbonic anhydrase IX)PSMA (Prostate-specific membrane antigen)
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