TM-25659

TM-25659 is a synthetic small molecule modulator of transcriptional co-activator with PDZ-binding motif (TAZ), also known as WW domain-containing transcription regulator 1 (WWTR1). Developed by Ewha Womans University and the Korea Research Institute of Chemical Technology (KRICT), TM-25659 promotes the nuclear translocation of TAZ. Once in the nucleus, TAZ suppresses peroxisome proliferator-activated receptor gamma (PPARγ)-mediated adipogenesis and enhances runt-related transcription factor 2 (RUNX2)-mediated osteoblast differentiation. Preclinical studies have demonstrated that TM-25659 reduces weight gain, prevents bone loss, and improves insulin resistance, hepatic steatosis, and inflammation in animal models of obesity, diabetes, and non-alcoholic fatty liver disease (NAFLD). Active therapeutic development of the compound has been discontinued, and it is now primarily utilized as a research tool.

Other names

2-butyl-5-methyl-6-(pyridine-3-yl)-3-[2'-(1H-tetrazole-5-yl)-biphenyl-4-ylmethyl]-3H-imidazo[4,5-b]pyridine