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TMC647055 + telaprevir
- Development stage
- Phase 1
- Lead developer
- Johnson & Johnson
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
TMC647055 + telaprevir is a **combination therapy** developed for the treatment of chronic hepatitis C virus (HCV) infection. **TMC647055** is a potent, selective, nonnucleoside small-molecule inhibitor of the HCV NS5B RNA-dependent RNA polymerase, binding to the NNI-1 allosteric site, thus inhibiting viral RNA replication. **Telaprevir** is a small-molecule inhibitor of the HCV NS3/4A protease, which is critical for viral polyprotein processing and RNA replication. This combination targets two different steps in the HCV replication cycle and is being investigated for synergistic antiviral efficacy and suppression of resistant viral mutations.
02
Targets
NS3/4A (Hepatitis C virus nonstructural protein 3/4A serine protease)NS5B (Hepatitis C virus non-structural protein 5B (NS5B) RNA-dependent RNA polymerase)
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