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TMLB-C16
- Development stage
- Unknown
- Lead developer
- China Pharmaceutical University
- Modality
- Small Molecules
01
Overview
TMLB-C16: sourced facts only. name: "The lead compound TMLB-C16 exhibited potent B3GAT3 inhibitory activity (KD = 3.962 μM) by effectively suppressing proliferation and migration, and inducing cell cycle arrest and apoptosis in MHCC-97H (IC50= 6.53 ± 0.18 μM) and HCCLM3 (IC50= 6.22 ± 0.23 μM) cells." [PMID:38919032]; target: "The lead compound TMLB-C16 exhibited potent B3GAT3 inhibitory activity (KD = 3.962 μM) by effectively suppressing proliferation and migration, and inducing cell cycle arrest and apoptosis in MHCC-97H (IC50= 6.53 ± 0.18 μM) and HCCLM3 (IC50= 6.22 ± 0.23 μM) cells." [PMID:38919032]; developer: "School of Science, China Pharmaceutical University, Nanjing 211198, China." [PMID:38919032]; modality: "These results indicate that compound TMLB-C16 is an effective small molecule inhibitor of B3GAT3, providing a basis for the future development of B3GAT3-targeted drugs." [PMID:38919032]
02
Targets
B3GAT3 (Beta-1,3-glucuronyltransferase 3)
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