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TMVP1-ICG
- Development stage
- Phase 1
- Lead developer
- Department of Obstetrics & Gynecology
- Modality
- Light/Condition-Responsive Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Peptide-Drug Conjugates → Peptide Conjugates → Peptides
- Administration
- Intralesional
01
Overview
TMVP1-ICG is an experimental **VEGFR-3-targeted near-infrared fluorescent imaging probe** developed at Tongji Hospital and Huazhong University of Science and Technology for visualization of cervical cancer and tumor-involved lymph nodes. It incorporates the tumor-homing pentapeptide TMVP1, with core sequence LARGR, and indocyanine green. TMVP1 has been reported to bind vascular endothelial growth factor receptor 3, also known as FLT4, a receptor associated with tumor lymphangiogenesis and metastatic lymphatic vessels. A ChiCTR study registered TMVP1-ICG, with the scientific title specifying TMVP1-PEG4-ICG, for local cervical injection before cervical-cancer surgery to support lymph-node mapping and lymph-node dissection. TMVP1-ICG is an imaging agent rather than an established anticancer therapy. ([chictr.org.cn](https://www.chictr.org.cn/showproj.html?proj=21264))
- Brand names
- TMVP1-ICGTMVP-1-ICGTMVP 1-ICG
- Other names
- TMVP1-PEG4-ICGTMVP-1-PEG4-ICGTMVP 1-PEG4-ICG
02
Targets
VEGFR3 (Vascular endothelial growth factor receptor 3)
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