TN140

TN140 (also known as TN14003 or T140) is a synthetic 14-residue peptide that acts as a potent and selective antagonist of the **C-X-C chemokine receptor type 4 (CXCR4)**. Originally derived from polyphemusin II, a peptide found in the horseshoe crab, TN140 blocks the interaction between CXCR4 and its natural ligand, **CXCL12** (SDF-1). This disruption interferes with the homing, retention, and survival of hematopoietic stem cells and various malignant cells within the bone marrow microenvironment. In preclinical models of hematologic malignancies, such as mixed lineage leukemia (MLL)-rearranged leukemia, TN140 has demonstrated the ability to mobilize leukemic cells into the peripheral blood, inhibit their proliferation, and induce apoptosis. TN140 served as a lead compound for the development of more stable clinical analogs, most notably **motixafortide** (BKT140/BL-8040).

Other names

4F-benzoyl-TN14003T140 analogT-140 analogT 140 analog