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tocilizumab-conjugated cisplatin nanoparticles
- Development stage
- Preclinical
- Lead developer
- Huazhong University of Science and Technology
- Modality
- Small Molecules, Monoclonal Antibodies → Antibody-Based Therapeutics, Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous, Parenteral
01
Overview
**Tocilizumab-conjugated cisplatin nanoparticles** are an investigational lipid-polymer hybrid nanomedicine designated **LPC-TCZ**. The formulation encapsulates the platinum chemotherapeutic cisplatin and is surface-functionalized with tocilizumab, an anti-interleukin-6 receptor monoclonal antibody. It was reported in preclinical non-small-cell lung cancer models to combine cisplatin-mediated DNA damage with IL-6 receptor blockade, thereby suppressing IL-6/STAT3-associated epithelial-mesenchymal transition, cancer stem-cell features, chemoresistance, tumor growth, and metastasis. ([mdpi.com](https://www.mdpi.com/1999-4923/17/7/945))
- Other names
- LPC-TCZ
02
Targets
IL-6R (Interleukin-6 receptor subunit alpha)DNA
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