tocopheryl nicotinate

Tocopheryl nicotinate is a fat-soluble small molecule ester composed of alpha-tocopherol (vitamin E) and nicotinic acid (niacin). Originally developed by Eisai and approved in Japan in 1967 under the brand name Juvela, it is primarily indicated for the treatment of hyperlipidemia and peripheral vascular disorders, including peripheral arterial disease. The compound functions as a vasodilator and antioxidant, improving microcirculation without the intense skin flushing typically associated with pure nicotinic acid. Beyond its role as a vitamin source, research indicates it may activate mitogen-activated protein kinases (MAPK) and influence fatty acid amide levels, suggesting distinct biological signaling roles.

Brand names

Juvela

Other names

alpha-tocopheryl nicotinatevitamin E nicotinatedl-alpha-tocopheryl nicotinate