tocopheryl phosphate mixture (Avecho Biotechnology)

Tocopheryl phosphate mixture (TPM) is a proprietary, lipid-based drug delivery technology developed by Avecho Biotechnology (formerly Phosphagenics). It is composed of a mixture of two phosphorylated forms of vitamin E: mono-tocopheryl phosphate (TP) and di-tocopheryl phosphate (T2P). TPM self-assembles into vesicular nanostructures that encapsulate active pharmaceutical ingredients (APIs), enhancing their solubility, stability, and absorption across dermal, transdermal, oral, and injectable routes. In addition to its role as a penetration enhancer and delivery vehicle, TPM possesses inherent anti-inflammatory and skin-soothing properties. It has been utilized in various clinical-stage formulations, including a transdermal patch for oxycodone (evaluated in Phase II trials for postherpetic neuralgia and pain) and an oral softgel capsule for cannabidiol (CBD) (in Phase III trials for insomnia).

Brand names

TPM

Other names

alpha-tocopheryl phosphate mixturetocopheryl phosphate mixture