Drug intelligence / Profile preview

TOL19-001

Development stage
Preclinical
Lead developer
Tollys
Administration
Oral
01

Overview

**TOL19-001** is a multi-ingredient oral dietary supplement marketed by Labrha as **Cicatendon** and subsequently as **Tenofort** for tendon health and tendinopathy. The capsule formulation contains spirulina, D-glucosamine sulfate, horsetail extract, ginseng, selenium, vitamin E, ferrous gluconate, and zinc gluconate. In cultured tendon-cell models exposed to interleukin-1β or ciprofloxacin, TOL19-001 reduced prostaglandin E2 production, matrix metalloproteinase expression, and type III collagen-associated changes, consistent with a broad anti-inflammatory and antioxidant effect rather than a defined single-target pharmacologic mechanism. Published clinical evidence includes an observational survey in patients with long-term tendinopathy; randomized controlled studies were stated to be needed. ([labrha-international.com](https://labrha-international.com/cicatendon-reduces-inflammation-and-mmp-expression-in-monolayer-cultures-of-tendon-cells-read-our-recent-publication-in-bmc-complementary-and-alternative-medicine/))

Brand names
CicatendonTenofort
Other names
TOL-19-001TOL19-001TOL 19-001
02

Targets

MMP1 (Matrix metalloproteinase-1)MMP3 (Matrix metalloproteinase-3)PGE2 (Prostaglandin E2)

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