Drug intelligence / Profile preview

Tolcylen

Development stage
Unknown
Lead developer
Marlinz Pharma
Modality
Small Molecules
Administration
Topical
01

Overview

Tolcylen is a physician-dispensed topical solution developed by Marlinz Pharma for the treatment of fungal nails (onychomycosis) and the improvement of non-fungal nail dystrophy. The formulation is a combination of the antifungal agent tolnaftate (1%) and undecylenic acid (25%), alongside urea, lactic acid, and propylene glycol which act as keratolytics and penetration enhancers. This multi-component approach aims to eradicate fungal infections by inhibiting squalene epoxidase while simultaneously debriding and hydrating the nail plate to restore its appearance. It is unique for its delivery system that allows the active ingredients to penetrate the nail bed without the need for systemic medication.

Brand names
TolcylenTolcylen Antifungal/Nail Renewal Solution
02

Targets

SQLE (Squalene monooxygenase)

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