tolfenamic acid

Tolfenamic acid is a non-steroidal anti-inflammatory drug (NSAID) of the fenamate class (anthranilic acid derivatives), primarily used for its analgesic and anti-inflammatory properties. It is indicated for the treatment of migraine headaches and other conditions associated with pain and inflammation. The drug acts mainly by inhibiting cyclooxygenase enzymes (COX-1 and COX-2), leading to reduced synthesis of prostaglandins, which are mediators of inflammation, pain, and fever. Tolfenamic acid also inhibits leukotriene synthesis and has been shown to partially inhibit leukotriene B4 chemotaxis in human polymorphonuclear leukocytes. Additionally, research suggests it may have anti-cancer activity by altering gene expression related to apoptosis, growth arrest, angiogenesis, and metastasis[1][2][3][6][8]. It was originally discovered by Medica Pharmaceutical Company in Finland[3].

Brand names

Clotam Rapid

Other names

Acide tolfenamiqueácido tolfenámicoAcidum tolfenamicum