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toll-like receptor agonist liposome
- Development stage
- Preclinical
- Lead developer
- CSPC NBP Pharmaceutical
- Modality
- Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
01
Overview
Toll-like receptor agonist liposome is an investigational liposomal formulation of a Toll-like receptor (TLR) agonist being developed by CSPC NBP Pharmaceutical (a subsidiary of CSPC Pharmaceutical Group) for the treatment of solid tumors. By encapsulating the TLR agonist within a liposomal delivery vehicle, the formulation is designed to enhance the delivery of the immune agonist to the tumor microenvironment, thereby promoting local immune activation and anti-tumor responses while minimizing systemic toxicity. The drug is currently in preclinical development.
- Other names
- Toll-like receptor agonist liposomeToll-like受体激动剂脂质体
02
Targets
CD14 (Monocyte differentiation antigen CD14)IRAK1 (Interleukin-1 receptor-associated kinase 1)IRAK4 (Interleukin-1 receptor associated kinase 4)IRF3 (Interferon regulatory factor 3)LY96 (Myeloid differentiation factor 2)MYD88 (Myeloid differentiation primary response protein MyD88)NF-κBTBK1 (TANK binding kinase 1)TLR1TLR4 (Toll-like receptor 4)TRAF6TLR7 (Toll-like receptor 7)TLR8 (Toll-like receptor 8)
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