Drug intelligence / Profile preview

toltrazuril

Development stage
Unknown
Lead developer
Bayer
Modality
Small Molecules
Administration
Oral
01

Overview

Toltrazuril is an antiprotozoal medication, specifically a coccidiostat, belonging to the triazine derivative class. It is primarily used in veterinary medicine to treat and prevent coccidiosis in various animals, including poultry, pigs, cattle, sheep, dogs, and cats. The drug works by disrupting the life cycle of coccidia parasites (such as Eimeria, Isospora, and Cyclospora species) within the host's intestinal cells. Its mechanism involves interfering with the protozoa's ability to reproduce, damaging their cellular structures, disrupting nuclear division, and impairing mitochondrial function, which leads to energy depletion and the destruction of the parasites at all life stages.

Brand names
VecoxanBaycoxTolcoxTotraCare
02

Targets

MRC (Coccidial mitochondrial respiratory chain enzymes)Coccidial nuclear division / mitotic machineryDHFR (Dihydrofolate reductase)DHODH (Dihydroorotate dehydrogenase (quinone), mitochondrial)EtCyp20.5 (Eimeria tenella cyclophilin EtCyp20.5)

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