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Tong Xie Yao Fang
- Development stage
- Unknown
- Lead developer
- Macrohard Institute of Health
- Administration
- Oral
01
Overview
Tong Xie Yao Fang (TXYF) is a traditional Chinese herbal formula primarily used for the treatment of irritable bowel syndrome (IBS), particularly the diarrhea-predominant subtype (IBS-D). The core formula consists of four herbal ingredients: largehead atractylodes rhizome (*Rhizoma Atractylodis Macrocephalae*), white peony root (*Radix Paeoniae Alba*), dried tangerine peel (*Pericarpium Citri Reticulatae*), and divaricate saposhnikovia root (*Radix Saposhnikoviae*). It is hypothesized to work by modulating the enteric nervous system and regulating neurotransmitters such as 5-hydroxytryptamine (5-HT) and substance P (SP). The Macrohard Institute of Health has sponsored clinical trials, including the PHIBEST study, to evaluate its efficacy and safety as a long-term treatment for IBS compared to conventional treatments like pinaverium bromide.
- Other names
- Formula for pain and diarrhea
02
Targets
TNFA (Tumor necrosis factor alpha (soluble))AKT1 (Proto-oncogene serine/threonine-protein kinase Akt1)HTR4 (5-Hydroxytryptamine receptor 4)
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