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Tongbian decoction
- Development stage
- Preclinical
- Lead developer
- Nanjing Drum-Tower Hospital
- Administration
- Oral
01
Overview
Tongbian decoction is a traditional Chinese medicinal formula primarily used to treat constipation, particularly slow transit constipation. Its therapeutic effects are mediated through multiple mechanisms, including the modulation of intestinal microbiota, activation of the 5-hydroxytryptamine (5-HT) signaling pathway, and regulation of intestinal motility. Additionally, it has been shown to inhibit cell autophagy via the PI3K/Akt/mTOR signaling pathway. The decoction is composed of a combination of various Chinese herbs, working synergistically to nourish Yin, aid defecation, regulate Qi, and distribute Jin.
- Other names
- Tongbian TangTongbian formula
02
Targets
HTR4 (5-Hydroxytryptamine receptor 4)CGRP (Calcitonin gene-related peptide)Autophagy (Autophagy machinery (ATG family))mTOR (Mammalian target of rapamycin kinase)NPYR (Neuropeptide Y receptors)PI3K (Phosphoinositide-3-kinase regulatory subunit 6)AKT (RAC-alpha serine/threonine-protein kinase)SP (Substance P)TPH1 (Tryptophan 5-hydroxylase 1)
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