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Tonglin Guben No. 1 Fang is a Traditional Chinese Medicine (TCM) herbal formula primarily developed and utilized in China for the treatment of chronic prostatitis and recurrent urinary tract infections. It is designed based on the TCM principles of clearing heat and promoting diuresis (Tonglin) while strengthening the vital essence and consolidating the foundation (Guben). The formula typically targets patients presenting with a pattern of spleen and kidney deficiency combined with damp-heat stasis. Clinical and pharmacological studies, often conducted at institutions like the Shenzhen Traditional Chinese Medicine Hospital, have demonstrated its efficacy in improving clinical symptoms such as urinary frequency, urgency, and pelvic pain. Research indicates that the formula exerts anti-inflammatory effects by downregulating the expression of pro-inflammatory cytokines, including interleukin-1 beta (IL-1β) and tumor necrosis factor (TNF), within the prostatic microenvironment.
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