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Tongren Niuhuang Qingxin Pills (同仁牛黄清心丸) is a prominent Traditional Chinese Medicine (TCM) formula produced by Beijing Tong Ren Tang, based on a modified prescription from the Song Dynasty. It is a complex multi-ingredient formulation containing 27 substances, including Calculus Bovis (cow gallstone), Radix Ginseng, Rhizoma Dioscoreae, and Radix Scutellariae. Traditionally, it is used to clear heat, resolve phlegm, and calm the mind, with primary indications for dizziness, palpitations, and speech impairment following a stroke. Modern clinical research, including studies involving the Third Affiliated Hospital of Beijing University of Traditional Chinese Medicine, has explored its efficacy in treating generalized anxiety disorder (GAD) and insomnia. The pharmacological profile of the formula involves the modulation of neurotransmitter systems, specifically acting as a positive allosteric modulator of GABAergic pathways and regulating serotonin levels, which contributes to its anxiolytic and sedative properties.
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