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Tongren Niuhuang Qingxin Wan
- Development stage
- Unknown
- Lead developer
- Beijing Tong Ren Tang
- Administration
- Oral
01
Overview
Tongren Niuhuang Qingxin Wan is a traditional Chinese medicine (TCM) formula developed and manufactured by Beijing Tong Ren Tang. Composed of 27 herbal and animal-derived ingredients—including artificial bezoar, antelope horn, artificial musk, ginseng, and buffalo horn concentrated powder—it is widely used to replenish vital energy (Qi) and blood, relieve convulsions, tranquilize nervous strain, and eliminate phlegm and wind. It is primarily indicated for the treatment and prevention of stroke, hemiplegia, facial paralysis, slurred speech, dizziness, vertigo, and palpitations. Recent pharmacological studies suggest that it may also exert antidepressant and anxiolytic effects by modulating the BDNF/TrkB/ERK/CREB signaling pathway and adrenergic signaling, thereby promoting hippocampal neurogenesis and synaptic plasticity.
- Brand names
- Tongren Niuhuang Qingxin Wan
- Other names
- Niuhuang Qingxin WanTongren Niuhuang Qingxin Pill同仁牛黄清心丸
02
Targets
ADRA2A (α2A)CREB1 (cAMP response element-binding protein 1)GIP (Glucose-dependent insulinotropic polypeptide)HIF1A (Hypoxia-inducible factor 1-alpha)MAPK3 (Mitogen-activated protein kinase 1)MIF (Oxidized macrophage migration inhibitory factor)NTRK2 (Tropomyosin-related kinase receptor type B)PIK3R1 (Phosphatidylinositol 4-phosphate 3-kinase regulatory subunit alpha)SRC (Proto-oncogene tyrosine-protein kinase Src)STAT3 (Signal Transducer and Activator of Transcription 3)VEGFA (Vascular endothelial growth factor A)
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