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Tongxie Anchang Formula
- Development stage
- Phase 2
- Lead developer
- Beijing University of Chinese Medicine East Hospital
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Tongxie Anchang Formula (TXACD) is a traditional Chinese medicine (TCM) herbal prescription developed by Professor Li Junxiang at Dongfang Hospital, Beijing University of Chinese Medicine. It is a multi-herb botanical drug composed of seven ingredients: Atractylodes macrocephala, Paeoniae Radix Alba, Coptidis Rhizoma, Rhizoma Zingiberis Preparata, Citrus reticulata, Cicadae Periostracum, and Mume Fructus. Indicated for diarrhea-predominant irritable bowel syndrome (IBS-D), particularly in patients with liver depression and spleen deficiency, the formula acts by regulating the NGF/TrkA signaling pathway to alleviate visceral hypersensitivity. It is currently being evaluated in Phase 2 clinical trials in China as a granule formulation.
- Other names
- Tongxie Anchang DecoctionTXACD通泻安肠方通泻安肠汤
02
Targets
TRPV1 (Transient receptor potential cation channel subfamily V member 1)NGF (Nerve growth factor)NTRK1 (Tropomyosin-related receptor kinase A)
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