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Tongxiening Granule
- Development stage
- Phase 4
- Lead developer
- The First Affiliated Hospital of USTC
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Tongxiening Granule is a Traditional Chinese Medicine (TCM) formulation developed by researchers at Anhui Provincial Hospital for the treatment of diarrhea-predominant irritable bowel syndrome (IBS-D). Derived from the classic "Tongxie Yaofang" formula, it consists of four primary herbal components: *Atractylodes macrocephala*, *Paeonia lactiflora*, *Citrus reticulata*, and *Saposhnikovia divaricata*. The drug works through multiple pathways, including the reduction of visceral hypersensitivity, modulation of the brain-gut axis (specifically targeting 5-hydroxytryptamine levels), and restoration of gut microbiota balance. Clinical studies have demonstrated its efficacy in improving abdominal pain and stool consistency in IBS-D patients by regulating inflammatory cytokines and intestinal barrier function.
- Brand names
- Tongxiening Granule
- Other names
- Tong-Xie-NingTongxiening
02
Targets
5-HT2 (5-HT2 receptor family)IL-6 (Interleukin 6)TNFA (Tumor necrosis factor alpha (soluble))CACNA1C (Voltage-dependent L-type calcium channel subunit alpha-1C)TJP1 (Tight junction protein 1 (ZO-1))5-HT (Serotonin receptors)
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