Drug intelligence / Profile preview

Tongxinluo

Development stage
Phase 4
Lead developer
Yiling Pharmaceutical
Modality
Small Molecules
Administration
Oral
01

Overview

**Tongxinluo** is an oral, multi-ingredient traditional Chinese patent medicine manufactured by Yiling Pharmaceutical. It is a fixed natural-product combination containing ginseng, leech, scorpion, red peony root, cicada slough, ground beetle, centipede, sandalwood, rosewood, processed frankincense, fried jujube seed, and borneol. In China, the hard-capsule product is indicated for coronary heart disease with angina and for stroke syndromes defined in traditional Chinese medicine as qi deficiency and blood-stasis obstruction. Its pharmacology is not attributable to a single molecular target; nonclinical data support pleiotropic vascular, antiplatelet, anti-inflammatory, endothelial-protective, lipid-modulating, and microcirculatory effects. Clinical and translational research has also evaluated it as adjunctive therapy in acute coronary syndrome, atherosclerotic plaque disease, and acute myocardial infarction. ([yiling.cn](https://www.yiling.cn/pro/tongxinluo-capsule/))

Brand names
TongxinluoTongxinluo Capsule通心络胶囊
Other names
Tongxinluo capsuleTongxinluo JiaonangTXL通心络胶囊
02

Targets

VEGFA (Vascular endothelial growth factor A)ET-1 (Endothelin-1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)NOS3 (eNOS)NOS2 (Nitric Oxide Synthase 2)

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