topical lingual PYY

Topical lingual PYY is a novel, intra-oral formulation of peptide YY (PYY), a well-known satiety hormone, developed for the treatment of obesity and cardiometabolic disorders. Unlike traditional systemic therapies, this drug is designed to be administered as a micro-dose that melts on the tongue in less than three seconds. It leverages the newly discovered "tongue-brain connection" by activating oral receptors that directly signal satiety centers in the brain—specifically targeting/activating the Nucleus Tractus Solitarius—without entering systemic circulation. This approach aims to reduce caloric intake and promote weight loss while avoiding side effects commonly associated with systemically delivered appetite-regulating drugs. The mechanism involves local activation of neural pathways regulating food intake and metabolism via oral sensory signaling rather than bloodstream-mediated action. Topical lingual PYY has completed Phase I clinical trials demonstrating strong efficacy with zero treatment-related adverse events[1][2][4].

Other names

Topical Lingual PYYPeptide YYPYY3-36PYY-3-36PYY 3-36