Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
topiramate
- Development stage
- Approved
- Lead developer
- Johnson & Johnson
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Topiramate is an oral small molecule anticonvulsant medication primarily used to treat epilepsy (including partial-onset and primary generalized tonic-clonic seizures) and to prevent migraine headaches. It is also used off-label for conditions such as bipolar disorder, weight loss (as part of a combination), alcohol dependence, essential tremor, and other neurological or psychiatric disorders. The drug acts through multiple mechanisms including blocking voltage-gated sodium channels; enhancing the activity of GABA-A receptors; antagonizing AMPA/kainate glutamate receptors; and inhibiting certain carbonic anhydrase isoenzymes. These actions reduce neuronal excitability in the brain[3][5][7]. Topiramate was originally developed by McNeil Pharmaceutical (now part of Johnson & Johnson)[5].
- Brand names
- TopamaxTrokendi XRQudexy XREprontiaTopamax Sprinkle
- Other names
- Topiragen
02
Targets
AMPAR (AMPA receptor)CA2 (Carbonic Anhydrase 2)Kainate-type ionotropic glutamate receptorCA4 (Carbonic anhydrase 4)GABRR (GABA-A receptor subunit rho)NaV (Voltage-gated sodium channels)
Beyond the preview
Go deeper on topiramate.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on topiramate.