Toraymyxin PMX-20R

**Toraymyxin PMX-20R** is a single-use extracorporeal hemoperfusion cartridge designed for the selective removal of endotoxin from circulating blood in patients with sepsis or septic shock associated with Gram-negative bacterial infection or endotoxemia[1][2][4][5][7]. Its mechanism utilizes **polymyxin B** immobilized on polystyrene derivative fibers to adsorb and bind endotoxins, preventing their systemic effects[1][4][5][7]. While polymyxin B is a potent antibiotic, its systemic use is limited by nephrotoxicity and neurotoxicity; immobilization on the cartridge enables safe extracorporeal removal of circulating endotoxins[1][4]. The device is indicated for use alongside standard medical care in intensive care settings and requires compatible hemodialysis or continuous renal replacement therapy (CRRT) equipment[4][5]. Clinical data indicate Toraymyxin improves hemodynamics, decreases vasopressor requirements, may improve oxygenation, and can reduce organ dysfunction and mortality in septic shock patients[1][3][4][8].

Brand names

Toraymyxin PMX-20RTORAYMYXINPMX

Other names

PMX cartridgePolymyxin B-immobilized fiber columnToraymyxinPMX-20R columnPMX20R columnPMX 20R column