torin1

Torin1 is a potent and selective small molecule inhibitor of the mechanistic target of rapamycin (mTOR), specifically inhibiting both mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2) through an ATP-competitive mechanism. Unlike rapamycin, which only partially inhibits mTORC1, Torin1 effectively blocks phosphorylation events mediated by both complexes, leading to robust inhibition of cell growth, proliferation, and survival pathways. It displays high selectivity for mTOR over related kinases such as PI3K and DNA-PK. In preclinical studies, Torin1 has demonstrated anti-cancer, anti-inflammatory, anti-aging properties and activity against neuropathic pain. It is also a strong inducer of autophagy due to its ability to mimic cellular starvation signals by blocking mTOR activity[3][4][5]. The compound was originally developed as a research tool for studying the biology of mTOR signaling.

Other names

TORIN1TORIN-1TORIN 1