Drug intelligence / Profile preview

Total Cold Medicine A - Kunihiro

Development stage
Unknown
Lead developer
Kokando Pharmaceutical
Modality
Small Molecules
Administration
Oral
01

Overview

Total Cold Medicine A - Kunihiro is an over-the-counter (OTC) multi-symptom cold remedy developed and marketed by Kokando Pharmaceutical Co., Ltd. in Japan. As a small molecule combination product, its primary active ingredient is ibuprofen, which serves as an antipyretic and analgesic to alleviate fever, headache, and joint pain. The formulation also includes additional active agents such as antihistamines (e.g., d-chlorpheniramine maleate) to treat runny nose and sneezing, decongestants/bronchodilators (e.g., dl-methylephedrine hydrochloride) for nasal stuffiness, and antitussives (e.g., dihydrocodeine phosphate) to suppress coughing. It is indicated for the relief of various symptoms associated with the common cold and is regulated as a Class 2 OTC drug in the Japanese market, specifically designed for use by adults aged 15 and older.

Brand names
Total Cold Medicine A - Kunihiro総合かぜ薬A「クニヒロ」
Other names
General Cold Medicine A KunihiroSogo Kazegusuri A KunihiroKokando Cold Remedy
02

Targets

HRH1 (Histamine H1 Receptor)PGHS-1 (Prostaglandin G/H Synthase 1)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)MOR (Mu opioid receptor)ADRB1 (β1)ADRA1 (Alpha-1 adrenergic receptor family)

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