total flavonoids of litchi seed

Total flavonoids of litchi seed (TFLS) refers to the complex mixture of bioactive flavonoid compounds extracted from the seeds of Litchi chinensis. These extracts are rich in various types of flavonoids, including but not limited to liquiritigenin, apigenin, naringenin, luteolin, dihydrokaempferol, daidzein, quercetin, taxifolin, kaempferol, isorhamnetin, myricetin, catechin and their glycosides such as rutin and baicalin[2][4][5]. TFLS has demonstrated broad-spectrum antitumor activities in preclinical studies. It inhibits proliferation and metastasis while inducing apoptosis in cancer cells—particularly prostate and breast cancer cell lines—by modulating pathways related to epithelial-mesenchymal transition (EMT), apoptosis (e.g., upregulation of E-cadherin and Bax; downregulation of Vimentin and Bcl-2), and stemness properties[3][4][7]. The extract is typically obtained via solvent extraction followed by purification steps such as column chromatography or HPLC. While traditionally used in Chinese medicine for urologic neoplasms including prostate cancer[4], its precise mechanism involves multiple molecular targets associated with tumor growth suppression.

Other names

total flavonoid of litchi seedtotal flavonoids from Litchi chinensis seedsTFLS