Drug intelligence / Profile preview

total ginsenosides

Development stage
Phase 2
Lead developer
China Pharmaceutical Research and Development Center
Modality
Small Molecules
Administration
Oral
01

Overview

Total ginsenosides refer to a standardized mixture of steroid-like saponins extracted from the roots, stems, or leaves of *Panax ginseng*. These compounds are the primary bioactive constituents responsible for the pharmacological effects of ginseng, particularly in cardiovascular and metabolic health. In the context of cardiovascular therapy, total ginsenosides exhibit cardioprotective properties by enhancing myocardial oxygen supply, reducing oxidative stress, and inhibiting platelet aggregation. They are known to promote vasodilation through the activation of nitric oxide synthase (NOS) and modulate calcium signaling by inhibiting L-type calcium channels. China Pharmaceutical Research and Development Center Co., Ltd. has developed specific preparations of total ginsenosides for the treatment of chronic stable angina pectoris, aiming to alleviate symptoms and improve cardiac function in patients with coronary heart disease.

Brand names
Ginsenoside
Other names
ginsenosidesPanax ginseng saponinstotal saponins of Panax ginsengginseng total saponins
02

Targets

NOS3 (eNOS)LTCC (Voltage-gated calcium channel (L-type))NOS1 (nNOS)

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