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total glycosides of rehmannia glutinosa leaves
- Development stage
- Unknown
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Total glycosides of rehmannia glutinosa leaves is a traditional Chinese medicine preparation derived from the leaves of Rehmannia glutinosa. It is used for its effects in nourishing yin and tonifying the kidney, cooling blood, and promoting blood circulation. The main clinical indication is mild chronic glomerulonephritis with symptoms such as proteinuria, hematuria, fatigue, weakness, hot palms and soles (hand-foot heat), lumbago (back pain), edema (swelling), dry mouth and throat, dizziness or tinnitus (ringing in the ears), red tongue with little coating or weak pulse[2][4][5]. The mechanism of action involves anti-inflammatory effects through inhibition of inflammatory cytokines and oxidative stress pathways; it may also have anti-fibrotic properties by inhibiting renal fibrosis progression[6]. The drug contains multiple bioactive compounds including catalpols and acteoside-like substances.
- Brand names
- adhesive rehmannia leaf total glycosides
- Other names
- 地黄叶总苷Di Huang Ye Zong Gantotal glycosides of rehmannia glutinosa leaves
02
Targets
HIF1A (Hypoxia-inducible factor 1-alpha)IL-6R (Interleukin-6 receptor subunit alpha)
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