total saponins from rubus parvifolius

Total saponins from rubus parvifolius are a purified extract of saponin compounds derived from the roots of *Rubus parvifolius* L., a plant used in traditional Chinese medicine. These saponins have shown both antitumor and neuroprotective activities in preclinical studies. In cancer models, total saponins from rubus parvifolius inhibit proliferation and induce apoptosis in human chronic myeloid leukemia cells via activation of AMPK and JNK signaling pathways and inhibition of the STAT3 pathway. In cerebral ischemia models, they protect against ischemia/reperfusion injury by decreasing neuronal apoptosis, upregulating anti-apoptotic factor Bcl-2, and downregulating pro-apoptotic factor Bax. Their mechanism is thus primarily through modulation of apoptosis-related signaling cascades. No evidence for commercial development or branding; studies have been conducted primarily by academic institutions in China[1][2].

Other names

total saponins of rubus parvifoliusTSRP