Drug intelligence / Profile preview

total saponins of radix clematidis

Development stage: Preclinical
Modality: Small Molecules
Administration: Oral, Topical

Overview

Total saponins of Radix clematidis (TSC) is a natural product extract derived from the roots and rhizomes of *Clematis* species, including *Clematis chinensis*, *Clematis hexapetala*, and *Clematis mandshurica*. It is the primary active fraction responsible for the anti-arthritic properties of the traditional Chinese medicine Wei-ling-xian. TSC is composed of various triterpenoid saponins, with clematichinenoside AR identified as a major active component. Research indicates that TSC exerts therapeutic effects in rheumatoid arthritis (RA) by inhibiting the excessive proliferation of fibroblast-like synoviocytes (FLS). This is achieved through the modulation of the lncRNA OIP5-AS1/miR-410-3p/Wnt7b signaling axis and the inhibition of the Wnt/beta-catenin signaling pathway. TSC also influences metabolic processes involving glycerophospholipids, sphingolipids, and arachidonic acid.

Other names: Total saponins of Clematidis Radix et RhizomaWei-ling-xian saponins

Targets

MYC (MYC proto-oncogene protein)WNT7B (Wnt family member 7B (commonly referred to as Protein Wnt-7b))miR-410-3p (MicroRNA 410-3p)OIP5-AS1 (OIP5 antisense RNA 1)GSK3 (Glycogen synthase kinase 3 beta)CTNNB1 (Beta-catenin)CCND1 (Cyclin D1)SFRP5 (Secreted frizzled-related protein 5)

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